CRK Polyclonal Antibody for Human(Homo sapiens) | EIAab.comCRK Polyclonal Antibody for Human(Homo sapiens)

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CRK (Gene name),

Adapter molecule crk (Protein name ), CRK_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CRK;

Protein name:

Adapter molecule crk;

Alternative:

p38;Proto-oncogene c-Crk;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ABL1, C3G, SOS, MAP4K1, MAPK8 and DOCK3 via its first SH3 domain. Interacts with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 via its SH2 domain upon stimulus-induced tyrosine phosphorylation. Interacts with several tyrosine-phosphorylated growth factor receptors such as EGFR, PDGFR and INSR via its SH2 domain (By similarity). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1. Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3; upon activation of EPHA3 by the ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent. Interacts with EPHA3 (phosphorylated); mediates EFNA5-EPHA3 signaling through RHOA GTPase activation.

Function:

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Subcellular Location:

Cytoplasm Cell membrane Translocated to the plasma membrane upon cell adhesion.

Protein Attributes:

Sequence length:

304

Sequence:

50:

100:

150:

200:

250:

300:

304:

EDFS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P46108

MIM:

164762

STRING:

9606.ENSP00000300574

Pfam:

PF00017

KEGG:

hsa:1398

UniGene:

Hs.461896

UniGene:

Hs.638121

String:

P46108

Uniprot:

P46108

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ELISA Kit for Human Adapter molecule crk

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E9658m

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96T

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ELISA Kit for Human Adapter molecule crk

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E9658h

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96T

ELISA Kit for Human Adapter molecule crk

Cat.:

E9658r

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96T

ELISA Kit for Human Adapter molecule crk

Cat.:

E9658c

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96T

CLIA Kit for Human Adapter molecule crk

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U9658c

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96T

CLIA Kit for Human Adapter molecule crk

Cat.:

U9658r

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96T

CLIA Kit for Human Adapter molecule crk

Cat.:

U9658h

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96T

CLIA Kit for Human Adapter molecule crk

Cat.:

U9658m

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96T

Polyclonal Antibody for Human Adapter molecule crk

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P9658Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Adapter molecule crk

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P9658Rb-h

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Polyclonal Antibody for Human Adapter molecule crk

Cat.:

P9658Rb-r

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Monoclonal Antibody for Human Adapter molecule crk

Protein for Human Adapter molecule crk

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Two species of human CRK cDNA encode proteins with distinct biological activities."
Matsuda M. , Tanaka S. , Nagata S. , Kojima A. , Kurata T. , Shibuya M.
Mol. Cell. Biol.12:3482-3489(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRK-II);FUNCTION;ALTERNATIVE SPLICING
tissue: Embryonic lung.
tissue: Placenta.
2.

"CRK proto-oncogene maps to human chromosome band 17p13."
Fioretos T. , Heisterkamp N. , Groffen J. , Benjes S. , Morris C.
Oncogene8:2853-2855(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRK-II)
4.

SeattleSNPs variation discovery resource
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRK-I)
6.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS CRK-I AND CRK-II)
tissue: Eye.
tissue: Lung.
tissue: Placenta.
9.

"DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane."
Hasegawa H. , Kiyokawa E. , Tanaka S. , Nagashima K. , Gotoh N. , Shibuya M. , Kurata T. , Matsuda M.
Mol. Cell. Biol.16:1770-1776(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOCK1
10.

"Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins."
Matsuda M. , Ota S. , Tanimura R. , Nakamura H. , Matuoka K. , Takenawa T. , Nagashima K. , Kurata T.
J. Biol. Chem.271:14468-14472(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOCK1; C3G AND EPS15;MUTAGENESIS OF ASP-150
11.

"Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction."
Koval A.P. , Karas M. , Zick Y. , LeRoith D.
J. Biol. Chem.273:14780-14787(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRS4
12.

"cbl-3: a new mammalian cbl family protein."
Keane M.M. , Ettenberg S.A. , Nau M.M. , Banerjee P. , Cuello M. , Penninger J. , Lipkowitz S.
Oncogene18:3365-3375(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBLC
13.

"Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation."
Matsumoto T. , Yokote K. , Take A. , Takemoto M. , Asaumi S. , Hashimoto Y. , Matsuda M. , Saito Y. , Mori S.
Biochem. Biophys. Res. Commun.270:28-33(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRA AND PDGFRB
14.

"NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway."
Lu L. , Anneren C. , Reedquist K.A. , Bos J.L. , Welsh M.
Exp. Cell Res.259:370-377(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
15.

"Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling."
Lawrenson I.D. , Wimmer-Kleikamp S.H. , Lock P. , Schoenwaelder S.M. , Down M. , Boyd A.W. , Alewood P.F. , Lackmann M.
J. Cell Sci.115:1059-1072(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL-CELL ADHESION;INTERACTION WITH EPHA3
16.

"DOCK4, a GTPase activator, is disrupted during tumorigenesis."
Yajnik V. , Paulding C. , Sordella R. , McClatchey A.I. , Saito M. , Wahrer D.C.R. , Reynolds P. , Bell D.W. , Lake R. , van den Heuvel S. , Settleman J. , Haber D.A.
Cell112:673-684(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOCK4
17.

"Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk."
Lennartsson J. , Wernstedt C. , Engstrom U. , Hellman U. , Ronnstrand L.
Exp. Cell Res.288:110-118(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIT;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION
18.

"Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways."
Salameh A. , Galvagni F. , Bardelli M. , Bussolino F. , Oliviero S.
Blood106:3423-3431(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLT4
19.

"Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor."
Roskoski R. Jr.
Biochem. Biophys. Res. Commun.337:1-13(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN KIT SIGNALING
20.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-239;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas."
Modzelewska K. , Newman L.P. , Desai R. , Keely P.J.
J. Biol. Chem.281:37527-37535(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCAR1; CDC42 AND TNK2
22.

"Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding."
Yang K.J. , Shin S. , Piao L. , Shin E. , Li Y. , Park K.A. , Byun H.S. , Won M. , Hong J. , Kweon G.R. , Hur G.M. , Seok J.H. , Chun T. , Brazil D.P. , Hemmings B.A. , Park J.
J. Biol. Chem.283:1480-1491(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDPK1
23.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-83;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
24.

"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
Voss M. , Lettau M. , Janssen O.
BMC Immunol.10:53-53(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FASLG
25.

"Unc119 protects from Shigella infection by inhibiting the Abl family kinases."
Vepachedu R. , Karim Z. , Patel O. , Goplen N. , Alam R.
PLoS ONE4:E5211-E5211(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH ABL1; ABL2 AND UNC119
26.

"Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression."
Wang Y. , Kelber J.A. , Tran Cao H.S. , Cantin G.T. , Lin R. , Wang W. , Kaushal S. , Bristow J.M. , Edgington T.S. , Hoffman R.M. , Bouvet M. , Yates J.R. III , Klemke R.L.
Proc. Natl. Acad. Sci. U.S.A.107:10920-10925(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PEAK1
27.

Wang Y. , Kelber J.A. , Tran Cao H.S. , Cantin G.T. , Lin R. , Wang W. , Kaushal S. , Bristow J.M. , Edgington T.S. , Hoffman R.M. , Bouvet M. , Yates J.R. III , Klemke R.L.
Proc. Natl. Acad. Sci. U.S.A.107:13556-13556(2010)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
28.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41 AND SER-74;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194 (ISOFORM CRK-I);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
29.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
30.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
31.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
32.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
33.

"Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide."
Donaldson L.W. , Gish G. , Pawson T. , Kay L.E. , Forman-Kay J.D.
Proc. Natl. Acad. Sci. U.S.A.99:14053-14058(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 12-120 IN COMPLEX WITH ABL1;INTERACTION OF THE CRK SH2 DOMAIN WITH PHOSPHORYLATED TYR-221
34.

"Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK."
Kobashigawa Y. , Sakai M. , Naito M. , Yokochi M. , Kumeta H. , Makino Y. , Ogura K. , Tanaka S. , Inagaki F.
Nat. Struct. Mol. Biol.14:503-510(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR (ISOFORMS CRK-I AND CRK-II);FUNCTION;PHOSPHORYLATION AT TYR-221

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